ABSTRACT
Aldehyde dehydrogenase 2 (ALDH2), as one of the most important alcohol metabolizing enzymes, plays a significant role in the detoxification process of acetaldehyde which is a main carcinogenic product of alcoholic metabolism. Alteration in its genotypes (particularly at the site of rs671) is closely associated with a variety of tumors in drinkers. Recent advance in the research of the association of the ALDH2 gene rs671 polymorphisms with cancer susceptibility in drinkers is reviewed.
Subject(s)
Humans , Alcohol Drinking , Genetics , Aldehyde Dehydrogenase , Genetics , Aldehyde Dehydrogenase, Mitochondrial , Genetic Predisposition to Disease , Neoplasms , Genetics , Polymorphism, GeneticABSTRACT
Objective To analyze the activities of cultured neuronal network in response to electric pulses stimuli with different intervals. Method Pairs of electric pulses with different intervals were added to rat hippocampal neurons cultured on multi-electrode arrays (MEA) substrate. Result The second response duration of the network increased with the decrease of the interval between two pulses. It was typical that the second duration after pulses with 10 ms interval increased greatly and it could be divided into two stages, i.e. quick response (within 10 ms) and slow response (near or beyond 100 ms). However, following pulses with 100 ms interval,there is practically no relation between the two responses; the second response duration was shorter and the number of spikes was fewer and their amplitudes were lower, which is similar to the result of single electric pulse stimulus. Conclusion The activity of cultured neuronal network was different in response to different electric stimulation patterns. Compared with spontaneous firing, the activity of the network is potentiated or depressed respectively after different stimulations.